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The Organic Chemistry of Drug Design and Drug Action (1) |  | Author: Richard B. Silverman Ph.D Organic Chemistry
Publisher: Academic Press
Category: Book
List Price: $77.95
Buy Used: $0.53
as of 7/31/2010 02:57 CDT details
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Seller: goodwill_industries_san_francisco
Rating:  6 reviews
Media: Hardcover
Edition: 1st
Pages: 422
Number Of Items: 1
Shipping Weight (lbs): 1.8
Dimensions (in): 9.5 x 6.6 x 1
ISBN: 0126437300
Dewey Decimal Number: 615.19
EAN: 9780126437300
Availability: Usually ships in 1-2 business days
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Product Description
This is a new approach to the teaching of medicinal chemistry. The knowledge of the physical organic chemical basis of drug design and drug action allows the reader to extrapolate to the many related classes of drugs described in standard medicinal chemistry texts. Students gain a solid foundation to base future research endeavors upon: drugs not yet developed are thus covered!
* Emphasizes the use of the principles of physical organic chemistry as a basis for drug design
* Discusses organic reaction mechanisms of clinically important drugs with mechanistic schemes
* Uses figures and literature references extensively throughout
* This text is not merely a "compilation of drugs and uses," but features selected drugs as examples of the organic chemical basis for any and all drug design applications
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| Customer Reviews:
Showing reviews 1-5 of 6
 Outstanding... May 5, 2005
Ashutosh Jogalekar (Somerville, NJ)
9 out of 9 found this review helpful
This is probably the best book of its kind in the vast and multidisciplinary field of drug design and action. Richard Silverman is an acclaimed chemistry professor at Northwestern University, and in this book he provides the most comprehensive and lucid exposition of the chemical basis of drug action that I have seen. No matter how complicated biological systems and their interactions are, at the basic level it's all chemistry, and mostly organic chemistry. Thus, understand the chemistry and you will go a long way in understanding drug action. An organic chemist will find this book extremely illuminating in a way that would not have been made clear through his traditional education.
The book opens with a short but clear discussion of drug discovery, combinatorial chemistry, patents and clinical trials. Then it leads the reader through a variety of enzyme catalyzed reactions, with examples of major drugs studded all the way. Silverman shows us how nature is the master organic chemist, employing the familiar reactions of chemistry in an unsurpassed manner. The chapter on enzyme inhibition is long and detailed and it's breathtaking. This is a key chapter because almost all major drugs act by inhibiting enzymes. The examples which Silverman chooses to illustrate are both important (including many bestselling anticancer, antiviral, and antibiotic drugs to name a few), as well as very interesting. The last parts of the book deal with DNA binding drugs and with pathways of drug metabolism and excretion. Along all the way, the emphasis is on the chemical reactions that drugs undergo, which are after all the key to understanding their properties. The lucidity of the book is such that a beginning graduate or advanced undergraduate well-versed with the basic principles of general and organic chemistry can easily understand all the contents.
I would say that this book is so interesting and illuminating that it's one of the very few academic books which you can enjoyably read cover to cover. In fact it even makes great bedside reading! Truly a must-have book for chemists and biologists of every kind interested in how drugs work.
Fantastic Book for chemists and medicinal chemists February 8, 2009
Eric Ballard (Charlottesville, VA United States)
1 out of 1 found this review helpful
Some books of this nature tend to focus on the synthesis of drug molecules and less about how they work and why. This book is just the opposite and walks the reader through a logical progression of drug discovery, design and target specificity. This book makes a great introduction to Goodman & Gilman's The Pharmacological Basis of Therapeutics which could be considered the bible of the subject.
Check out the new edition of this book February 4, 2004
3 out of 5 found this review helpful
There is a new considerably expanded and updated edition available of Silverman's already classic text as of Jan/04. ISBN is 0-12-643732-7. Check it out... price is comparable to the earlier edition.
Excellent! February 9, 2010
Randall J. Gratchick (USA)
0 out of 1 found this review helpful
The book was brand new just like it said in the description and it was shipped very fast.
 Excellent April 5, 2004
Downtown Mr. Brown (Toronto)
1 out of 2 found this review helpful
This book is fantastic and covers a broad range of topics that fall into the category of rational drug design. The book goes in depth into topics dealing with each important aspect of how drugs are discovered and modified to produce better drugs: from effects of chirality to electronic effects. The structure of drugs, at the molecular level are covered in detail, reflecting every major aspect of drug structure. Then, interaction between drug (ligand) and enzyme, at the molecular level are covered.
In my estimation, to benefit most from this book, the reader should have a working knowledge of organic chemistry and biochemistry (at least protein secondary and tertiary structure).
Showing reviews 1-5 of 6
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